Effects of diazoxide-cardioplegia on electrophysical properties of guinea pig myocardium
- VernacularTitle:含二氮嗪停搏液对豚鼠心肌电生理的影响
- Author:
Kailun ZHANG
;
Yunhai YANG
;
Zhiwei HU
- Publication Type:Journal Article
- Keywords:
Diazoxide Cardioplegic solutions Myocardium Electrophysiology
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of on modified St.Thomas solution with mitochondrial ATP-sensitive potassium channel opener diazoxide on guinea pig papillary muscles protection after myocardial hypoxia. Methods: Twenty-four guinea pigs were randomly divided into three groups. In control group, cardioplegia was routine St.Thomas solution. In treatment group, cardioplegia was used modified St.Thomas solution. In blocker group, the muscle was treated with the specific potassium channel blocker glibenchamide 15 minutes before arrest used diazoxide cardioplegia. Myocardial electrophysical before and after cardioplegic arrest in guinea pig papillary muscles were studied. Results: 1, Time of recovery was shortened significantly in treatment group (P
