Nuclear Factor-kappaB (NF-kappaB) Activity and Levels of IL-6, IL-8 and TNF-alpha in Induced Sputum in the Exacerbation and Recovery of COPD Patients.
10.4046/trd.2005.58.2.152
- Author:
So Hyang SONG
1
;
Chi Hong KIM
;
Soon Seog KWON
;
Young Kyoon KIM
;
Kwan Hyoung KIM
;
Hwa Sik MOON
;
Jeong Sup SONG
;
Sung Hak PARK
Author Information
1. Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea 93 Chi-dong, Paldal-ku, Suwon, 442-723, Korea. chihongk@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
COPD;
exacerbation;
NF-kappa B;
IL-6;
IL-8;
TNF-alpha
- MeSH:
Cell Count;
Humans;
Inflammation;
Interleukin-6*;
Interleukin-8*;
Macrophages;
NF-kappa B;
Pulmonary Disease, Chronic Obstructive*;
Sputum*;
Tumor Necrosis Factor-alpha*
- From:Tuberculosis and Respiratory Diseases
2005;58(2):152-159
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are thought to be associated with increased airway inflammation, and the NF-kappa B is known to be an indicator of cellular activation and of inflammatory mediator production. This study was undertaken to investigate the change of cytokine characteristics and NF-kappa B activity in induced sputum of COPD patients during exacerbation and recovery of the disease. METHODS: Sputum induction was performed in 37 patients with COPD during exacerbation and during recovery and in 15 healthy subjects. Cell counts, levels of IL-6, IL-8 and TNF-alpha in induced sputum and NF-kappa B activity in macrophage of induced sputum were measured. RESULTS: Patients with COPD showed significantly increased levels of IL-6, IL-8 and TNF-alpha(p<0.01) and increased NF-kappa B activity in induced sputum(p<0.05) as compared with control subjects. Level of IL-8 during exacerbation of COPD decreased significantly during recovery(p<0.05). NF-kappa B activity and levels of IL-6 and TNF-alpha tended to be decreased during recovery, but not siginificantly. CONCLUSION: Activation of NF-kappa B and increased levels of IL-6, IL-8 and TNF-alpha were thought to be associated with pathogenesis and exacerbations of COPD.
