THE EXPRESSION OF CONNEXIN 43 IN HUMAN CARDIAC CONDUCTION SYSTEM
- VernacularTitle:成人心脏传导系统中连接蛋白43的表达
- Author:
Zhengrong MAO
- Publication Type:Journal Article
- Keywords:
Connexin 43(CX43);
Conduction system;
Immunohistochemistry;
Adult heart
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To study the expression of connexin 43 in human cardiac conduction system(CCS) and heart. Methods The distribution of CX43 was studied immunohistochemically using of SABC method with antibody CX43. Results Smaller amounts of CX43 can be seen in the nodal myocytes at the periphery of sinoaterial and atrioventricular node whereas in the myocytes at the center of nodes were negative. In the Purkinje fibers, abundant expression of CX43 was found, and in atrial and ventricular myocardium contained abundant amounts of CX43, especially in the intercatalated disk.Conclusion The expression of connexin 43 varies greatly in specific regions of the human heart with different conduction properties. These differences may play a role in regulating electric impulse of cardiac conduction.
