Relation of inducible nitric oxide synthase and angiogenesis to the progression of gastric carcinoma
- VernacularTitle:一氧化氮合酶和微血管生成与胃癌发展的关系
- Author:
Wenhui TAO
;
Changsheng DENG
;
Youqing ZHU
- Publication Type:Journal Article
- Keywords:
Gastric carcinoma;
Nitric oxide synthase;
Angiogenesis;
Microvessel density
- From:
Chinese Journal of Digestion
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of inducible nitric oxide synthase (iNOS) in human gastric carcinoma and its relationship with angiogenesis, lymph nodes metastasi s and clinical staging of gastric carcinoma. Methods The expression of iNOS in 50 patients with gastric carcinoma was studied with im munohistochemical method. Microvessel density (MVD) of human gastric carcinoma was also determined with anti-CD34 as the labelled vascular endothelial cells. Results The rate of expression of iNOS in 50 cases of gastric carcinoma was 70.0% , and MVD averaged 22.0?9.8, higher than those in the tissues around cancer (16 .2%,6.1?3.4) and normal gastric tissues (15.0%,5.5?2.6; P
