Mechanism of hypersensitivity in the patients with irritable bowel syndrome
- VernacularTitle:肠易激综合征患者内脏高敏感性的机制研究
- Author:
Wenzhu DONG
;
Duowu ZOU
;
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Mast cell;
Substance P;
Vasoactive intestinal ploypept ide;
Hypersensitivity
- From:
Chinese Journal of Digestion
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the rectal visceral perception to balloon distention and the changes o f mast cells (MCs), substance P(SP) and the vasoactive intestinal ploypeptide(VI P) in irritable bowel syndrome(IBS), and to investigate their possible roles in IBS. Methods The biopsies of the terminal ileum, the ilecocecal junctio n(ICJ), the ascending colon and the sigmoid colon were stained with histochemist ry fo r the MCs and with immunohistochemistry for SP and VIP in 19 controls, 22 diarrh ea-predominant IBS (D-IBS) patients and 20 constipation-predominant IBS (C-I BS) patients. The results were investigated qualitatively and quantitatively by color image analyzer. The structural relation between MC and nerves or cells was studied through an ultramicroscopy. Rectal visceral perception thresholds to b alloon distention, rectal compliance and anorectal manometry were examined by me ans of electric barastat and perfusion catheter manometer. Results The number of the MCs in the terminal ileum, ICJ and ascen ding colon was significantly elevated in IBS patients ( P 0.05); rectal complianc e decreased significantly ( P
