Therapeutic effect of ~(99m)Tc-MDP and its role in proinflammatory cytokines in rheumatoid arthritis
- VernacularTitle:~(99m)Tc-亚甲基二膦酸盐在类风湿关节炎的疗效及其对炎性细胞因子的抑制作用
- Author:
Rong MU
;
Shi CHEN
;
Zhanguo LI
;
Limin REN
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Technetium Tc 99m medronate;
Interleukin-1;
Tumor necrosis factor
- From:
Chinese Journal of Rheumatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of 99m Tc-MDP on clinical and laboratory parameters in rheumatoid arthritis(RA).Methods The study was a prospective open cohort design.Clinical manifestations were recorded accordingly before and after 99m Tc-MDP intravenous infusion.Serum CRP,IL-1?,TNF-?and ESR were also measured.Results At the end point,morning stiffness,strength,index of joint tenderness,swelling,rest pain and physician assessment were all improved significantly(P
