Low-dosage harringtonine for treating lupus nephritis
- VernacularTitle:小剂量三尖杉酯碱治疗狼疮肾炎
- Author:
Jianting ZHONG
;
Xuan WANG
;
Li LIU
;
Chunsheng XI
;
Yizhen JIANG
;
Jing CHEN
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Clinical protocols;
Harringtonine
- From:
Chinese Journal of Rheumatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effect of low-dose herringtonine in lupus nephritis.Methods Harringtonine1mg,which was dissolved in500ml normal saline,was infused intravenously everyday for5to7days as a single course.The total therapeutic period was consisted of3to6courses.Each course was given every2to3weeks.12patients with lupus nephritis were treated in this study.Results Seven patients(58%)achieved complete clinical remission while5(42%)had partial clinical remission.The overall response rate was100%.Conclusion This study suggests that low-dose harringtonine is an effective therapeutic regimen for lupus nephritis with relatively low toxicity and low price.It has the potential to be used widely in treating lupus nephri-tis.
