Preliminary study of a vincristine-producing endophytic fungus isolated from leaves of Catharanthus roseus
- VernacularTitle:一株产长春新碱内生真菌的初步研究
- Author:
Xianzhi YANG
;
Lingqi ZHANG
;
Bo GUO
;
Shipin GUO
- Publication Type:Journal Article
- Keywords:
Catharanthus roseus (L.) G. Don;
Mycelia sterilia;
endophytic fungi;
vincristine
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To select the endophytic fungi which produce vincristine by isolating fungi from the leaves of Catharanthus roseus (L.) G. Don. Methods The endophytic fungi were isolated from the leaves of C. roseus and the zymotic extracts were analyzed by TLC and HPLC. Results An endophytic fungus which is Mycelia sterilia 97CY_3 can produce vincristine. The content of vincristine in the fungus was determined as 0.205 ?g/L by HPLC. Conclusion Some endophytic fungi isolated from C. roseus can produce the anticancer substance vincristine which is the same as that of host plant producing.
