The changes and evaluation of P-selectin、CRP、IL-6 、TNF-?and ICAM-1 in acute coronary syndrome
- VernacularTitle:急性冠脉综合征患者血浆P-选择素、C-反应蛋白、白介素-6、肿瘤坏死因子-?和细胞间黏附分子-1变化及其临床意义
- Author:
Weiheng WU
;
Lin ZHU
;
Jun DIAO
- Publication Type:Journal Article
- Keywords:
P selectin;
CRP;
IL 6;
TNF ?;
ICAM 1;
ACS;
CHD
- From:Journal of Interventional Radiology
2003;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation of inflammation markers to acute coronary syndrome and the clinical significance by observing the changes of P selectin、CRP 、IL 6、TNF ?、ICAM 1 during unstable agina pectoris and acute myocardial infarction(AMI). Methods 45 patients were selected as acute coronery syndrome(ACS)group, including 25 patients with unstable agina pectoris (UAP) and 20 patients with AMI; 25 patients as stable agina pectoris (SAP)and 20 persons as control group. The blood sample of the control group are drawn from venous in the morning, the agina pectoris group are drown from venous in the morning of the second day after hospitalized, however, the AMIgroup are drown from venous at the point of 6 hour、 12 hour、24 hour、48 hour、72 hour after episode. The concentration of CRP is determined by Scatter Turbidimetry , and the concentration of P selectin、IL 6 、TNF ?、ICAM 1 by ELISA. Results (1) SAP vs control ,the levels of P selectin、CRP 、IL 6、TNF ?、ICAM 1 all raise significantly ( P 0.05) ; (4) AMI vs SAP , the levels of P selectin、CRP 、IL 6、TNF ?、ICAM 1 all raise significantly ( P
