Effect of Xiange Granule on osteoporosis in ovariectomized rat model
- VernacularTitle:仙葛颗粒对去卵巢骨质疏松大鼠模型的影响
- Author:
Xiaojin HE
;
Jihong PENG
;
Xiaodong HE
;
Weijun XIA
- Publication Type:Journal Article
- Keywords:
Xiange Granule;
osteoporosis;
bone mineral density;
bone metabolism;
microstructure
- From:
Chinese Journal of Biochemical Pharmaceutics
2009;30(6):397-399,403
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the effect of Xiange Granule on osteoporosis in ovariectomized rat model and explore the mechanism of prevention and treatment of osteoporosis.Methods 60 female rats were randomly divided into blank control group, model group, Xiange Granule low, middle and high-dose group, CEE3 group of 6 groups. The method used ovariectomy made animal model of postmenopausal osteoporosis. Gavage after 3 months measured femur bone mineral density, calcitonin, bone gla protein and estradiol concentration, observed cancellous bone of femur with electron microscope.Results Xiange Granule could significantly increase the bone mineral density, calcitonin, bone gla protein and estradiol levels of the ovariectomized rat model and improve the microstructure of cancellous bone.Conclusion Xiange Granule is effective for prevention and treatment on osteoporosis.
