Effects of Fas ligand gene on vascular remodeling in rat carotid artery after balloon injury
- VernacularTitle:Fas配体基因对大鼠颈动脉球囊损伤后血管重塑的影响
- Author:
Hong TAO
;
Lidong CHEN
;
Congxin HUANG
- Publication Type:Journal Article
- Keywords:
Fas Ligand;
Vascular Remodeling;
Smooth Muscle;
Vessel;
Rat
- From:Journal of Interventional Radiology
2003;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Fas ligand gene on vascular remodeling in rat carotid artery after balloon injury. Methods The rat carotid artery model after balloon injury was performed .Twelve SD rats were randomizely assigned to ① control group Ad ?gal ② FasL group . Fourteen days after balloon injury in situ perfusion fixation was performed with 10% formalin and the carotid artery specimens were obtained . Morphometric analysis were performed. Results FasL significantly reduced intimal area(IA) , increased lumen area (LA) and external elastic lamina area (EEL) Conclusions FasL has the role of promoting favorable vascular remodeling of injuied vessel.
