Expression of PTEN,CDK4 protein in endometrial carcinoma and its clinical significance
- VernacularTitle:PTEN、CDK4蛋白在子宫内膜癌中的表达及其临床意义
- Author:
Liangdan TANG
- Publication Type:Journal Article
- Keywords:
PTEN protein;
CDK4 protein;
Endometrial carcinoma;
Immunohistochemistry
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between cyclin dependent kinase 4 (CDK4),PTEN protein expression and carcinogenisis,progression and recurrence of endometrial carcinoma.Methods:A specific and sensitive immunohistochemical S-P assay was used to detect the expression of PTEN and CDK4 in paraffin-embedded sections of 50 cases of endometrial carcinoma,12 atypical hyperplasia of endometrium and 10 normal endometrium.Results:1.The positive immunostainning rates of PTEN in endometrial carcinoma,atypical hyperplasia of endometrium and normal endometrium were 56.00%,91.00%,100.00%,respectively;and the difference was statistically significant between carcinoma and normal endometrium or atypical hyperplasia of endometrium(P1/2 muscle invasion cancer and in recurrence cases.Conclusion:The results suggest that the aberrant expressions of PTEN and CDK4 are closely related to the occurrence,development and recurrence of endometrial carcinoma.
