Effect of magnesium sulfate on excitatory amino acids following traumatic brain injury in rats
- VernacularTitle:硫酸镁对大鼠创伤性脑损伤兴奋性氨基酸的影响
- Author:
Quanhong SHI
- Publication Type:Journal Article
- Keywords:
Traumatic brain injury;
Magnesium sulfate;
Excitatory amino acids;
Glutamate;
Aspartate
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the level of excitatory amino acids in the cerebrospinal fluid and the effect of magnesium sulfate on the excitatory amino acids following traumatic brain injury. Methods:The Feeney′s model of the excitatory amino acids in the cerebrospinal fluid (glutamate and aspartate) were measured by amino acid analysis from rats in different time. Results:1. The glutamate and aspartate in the cerebrospinal fluid increased largely 2 hours after traumatic brain injury(P0.05).2.Magnesium inhibited strongly the releasing of the excitatory amino acids at 2h and 8h after the traumatic brain injury(P0.05).Conclusion:Plenty releasing of excitatory amino acid may play an important role at the phase of posttraumatic neuronal injury.Magnesium sulfate can inhibit early releasing of excitatory amino acids.Administering magnesium sulfate may be the optimal choice for treating traumatic brain injury.
