Growth factor plays a role in the forming and progressing process of experimental uric acid granulomas
- VernacularTitle:生长因子在实验性尿酸盐肉芽肿形成和转归中的作用
- Author:
Man XU
- Publication Type:Journal Article
- Keywords:
Transform growth factor-? 1(TGF-? 1);
Granuloma
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the expression of TGF-? 1 and the formation and progression of experimental uric acid granulomas in rats.Methods:The formation and progression of granulomas in 30 cases of uric acid nephropathy,the expressions of protein and mRNA of TGF-? 1,moreover PCNA,?-SMA and collagen Ⅲ were investigated with ABC immunohistochemical staining and in situ hybridization techniques.Results:The mononuclear cells in granulomas and the injured renal tubular cells expressed TGF-? 1mRNA,and synthesized protein of TGF-? 1 and PCNA.In the late stage,the degree of the expression of TGF ? 1 and the deposition of collagen Ⅲ were in coincidence in granulomas.Conclusion:TGF-? 1 promotes the forming of granulomas by stimulating the proliferation in situ of mononuclear cells through autocrine and paracrine,and plays important roles in fibrosis of granulomas.
