Effect of BushenYizhi Prescription on Long-Term Potentiation in Hippocampus of Ovariectomized Rats
- VernacularTitle:补肾益智方对卵巢切除大鼠海马长时程增强的影响
- Author:
Jieming ZHOU
;
Shilong LAI
;
Yan RAO
;
Jingqing HU
- Publication Type:Journal Article
- Keywords:
@ Bushen Yizhi Prescription/pharmacology;
Long-item potentiation;
electrophysiology
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Bushen Yizhi Prescription(BYP) on long-term potentiation (LTP) in hippocampus of ovariectomized (OVX) rats. Methods Three-month-old female SD rats were randomized into mimic operation group, model group, low dosage BYP group, high dosage BYP group and estrogen control group. Ovariectomy was operated in the three latter groups. After operation, BYP group was treated with gastric infusion of BYP and estrogen group with subcutaneous injection of estrogen. The changes of LTP of dentate gyms in hippocampus of OVX rats were observed by electrophysiological method and the effect of BYP on LTP was also evaluated. Result & Conclusion The increased amplitude of population spike of LTP was significantly low and maintained a short time in model group as compared with that in mimic operation group. There were insignificant difference between the high-dosage BYP group and estrogen control group. It is indicated that synaptic transmission in hippocampus can be protected and sustained by BYP and the estrogen replacement.
