Experimental Study on Effects of Qingxiang Concentrated Pill on Mammary Gland Hyperplasia in Rats
- VernacularTitle:青香丸(浓缩丸)对大鼠乳腺增生的影响
- Author:
Xueying MA
;
Chengren LIN
;
Min WANG
;
Tiren SHI
;
Hongxin ZONG
;
Lianda LI
- Publication Type:Journal Article
- Keywords:
@ Qingxiang pill/pharmacology;
Fibrocystic disease of breast/TCD therapy;
Fibrocystic disease of breast/physiopathology;
Disease models, animal
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of Qingxiang Concentrated Pill (QCP) on mammary gland hyperplasia (MGH) in rats. Methods Injection of estradiol were given to establish rat models of MGH and QCP was given QCP at the same time. Pathologic changes of mammary gland in rats were observed under light microscope. Changes of breast diameter, mammary gland volume and weight were measured; serum sex hormones levels, SOD activity and MDA content were also estimated. Results QCP could decrease the increased breast diameter, mammary gland volume and weight, reduce the numbers of mammary gland lobules and mammary acini and the diameter of acinar cavities. It could also decrease eatradiol level and MDA content in serum, inhibit the decrease of the coefficient of thymus and increase the serum progesterone level. Conclusion QCP can regulate sex hormone levels, inhibit lipid peroxidation and relieve the pathologic changes of mammary gland in MGH rats.
