An experiment study on myocardial regeneration with implantation of bone marrow cells into infarct myocardium
- VernacularTitle:急性心梗后骨髓细胞心肌内移植促进心肌细胞再生的实验研究
- Author:
Feng LIN
;
Chongxian LIAO
;
Yunbin YE
- Publication Type:Journal Article
- Keywords:
Bone marrow cell Cell trasplantation Myocardial infarction Myocardium Regeneration
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of bone marrow cells on myocardial regeneration. Methods: Bone marrow cells were implanted into the acute myocardial infarct via topical injection. Specimens were harvested at 1st, 2nd, 4th, 8th weeks after bone marrow cells implantation for morphologic examination. Results: Bone marrow cells with fluorescence had been observed in the implanted site. A portion of the implanted cells had differentiated into myogenic cells. The regenerating myocardial cells observed by electron micrography had been connected with the host myocardium through intercalated discs. The infarct size was significantly smaller in implant group. Conclusion: This study suggested that bone marrow cells are capable to differentiate and regenerate into myocardial cells in the acute myocardial infarct sites and reduce size of infarct.
