Nogo(N-18) EXPRESSION IN NORMAL RETINA AND AFTER THE OPTIC NERVE INJURY IN HAMSTERS
- VernacularTitle:正常和视神经损伤后Nogo(N-18)在金黄地鼠视网膜的表达
- Author:
Jiliang LEI
;
Lei YANG
;
Junpeng ZHAO
;
Si LIU
;
Zefeng WEI
;
Enhu YU
- Publication Type:Journal Article
- Keywords:
CNS regeneration;
Nogo protein;
Retina;
Immunohistochemistry;
Hamsters
- From:
Acta Anatomica Sinica
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distribution of Nogo-A in the retina and the changes after the optic nerve(ON) injury in hamsters. Methods In this experiment,ON was crushed at 2?mm behind of the eyeball.After 3?d,5?d and 7?d post-axotomy,the Nogo antiserum immunoreactive staining on section of the retina was performed. Results Nogo was expressed at every layer of the retina with the strongest expression on 3?d post-axotomy.The numbers of Nogo-A positive RGCs decrease as the survived time increased.Conclusion Nogo-A in the retina is not unique secretion from the neuroglia.The change in the distribution and level of expressed of Nogo-A in the retina is correlated with time advancement after injured of ON.
