Relationship of nuclear transcription factor-?B/interleukin-8 with angiogenesis and prognosis of gastric cancer
- VernacularTitle:核转录因子/白细胞介素-8与胃癌血管生成及预后关系研究
- Author:
Zhenbao YE
;
Gui CHEN
;
Yinyan YU
- Publication Type:Journal Article
- Keywords:
Nuclear transcription factor-?B;
Interleukin-8;
Gastric cancer;
Microvessel density
- From:
Chinese Journal of Digestion
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To disclose the implication of nuclear transcription factor(NF)-?B and interleukin(IL-8) in the angiogenesis and prognosis of gastric cancer. Methods The expressions of NF-?B, IL-8 and microvessel density (MVD) in 41 samples of gastric cancer were detected by immunohistochemistry. Results NF-?B and IL-8 were positive in 28 samples (68.3%) and 12 samples (29.3%) respectively. NF-?B, but not IL-8, was related to MVD significantly( P =0.002), and there was significant relationship between the expressions of NF-?B and IL-8 and TNM staging( P
