Clinical Significance of Urokinase-type Plasminogen Activator (uPA) Expression from Serum and Tissue of Gastric Cancer Patients.
- Author:
Hyun Cheol CHUNG
1
;
Joon Oh PARK
;
Hyun Ja KWON
;
Tae Soo KIM
;
Hei Cheol CHUNG
;
Soo Jung GONG
;
Hwa Young LEE
;
Sun Young RHA
;
Nae Choon YOO
;
Joo Hang KIM
;
Jae Kyung ROH
;
Sung Hoon NOH
;
Jin Sik MIN
;
Byung Soo KIM
Author Information
1. Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
uPA;
PAI-1;
Gastric cancer;
Serum;
Tissue
- MeSH:
Enzyme-Linked Immunosorbent Assay;
Humans;
Plasminogen Activator Inhibitor 1;
Plasminogen Activators;
Stomach Neoplasms*;
Urokinase-Type Plasminogen Activator*
- From:Journal of the Korean Cancer Association
1997;29(5):765-773
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We measured the gastric cancer tissue uPA and plasminogen activator inhibitor-1 (PAI-1) levels and compared them to those of the peripheral and portal blood levels to evaluate the correlation. MATERIALS AND METHODS: Tissue uPA and PAI-1 levels were measured by ELISA assay (Monozyme, Netherland) in paired 85 normal and cancer tissues resected from gastric cancer patients. In 50 patients, blood uPA and PAI-1 levels were measured from pre- operative peripheral and portal blood, post-operative portal blood. RESULTS: Gastric cancer tissue uPA and PAI-1 levels increased from the early stage. The elevated cancer-to-normal ratios of the uPA and PAI-1 were constant from stage I to IV. There were correlations of uPA between normal and cancer tissues (r2=0.38) and between peripheral and pre-resection portal blood level (r2=0.64). There were no correlations between tissue PAI-1 level and blood PAI-1 levels. However, there were correlations in PAI- 1/uPA ratio between cancer tissue and peripheral blood (r2=0.25), peripheral blood and pre- resection portal blood (r2=0.60). CONCLUSION: Even if the cancer tissue levels of uPA and PAI-1 increased from the early stage of gastric cancer, only blood uPA level correlated with tissue uPA level. A modest correlation found in PAI-1/uPA ratio between cancer tissue and blood suggests applicability of blood PAI-1/uPA ratio in predicting tissue uPA, PAI-1 expression.
