The curative effects of Lamivudine αcombined with IFN in treatment of chronic hepatitis B

VernacularTitle:拉米夫定联合干扰素治疗慢性乙型肝炎疗效分析
Author: Lingxiang JIANG
Publication Type:Journal Article
Keywords: Lamivudine; IFNα-1b; Hepatitis B,chronic
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(17):2344-2345,后插三
CountryChina
Language:Chinese
Abstract: Objective To explore the curative effects of Lamivudine combined with IFNα-1b in treatment of chronic hepatitis B. Methods 120 patients with chronic hepatitis B were divided into 3 groups. Patients in group A were treated with IFNα-2b 3 times a week for 26 weeks. Patients in group B were treated with Lamivudine one time a day for 52 weeks. Patients in group C were treated with IFNα-1b and Lamivudine symphysially. The serum indexes were observed and the clinical effects were evaluated. Results The ALT and AST levels in 3 groups were all decreased significantly(P ＜0. 01) after treatment. However,the ALT and AST in group C was lower than that of the other 2 groups(P ＜0. 05). Also there was a statistical difference(P ＜0. 05) between the effective rate of the group C and that of other 2 groups. Conclusion Treating chronic hepatitis B with Lamivudine and IFNα-1b federatively was more effective than using a single medicine.