Expression and significance of p27kip1, CyclinD1, Cyclin E in transitional cell carcinoma of bladder

VernacularTitle:p27kip1、CyclinD1、CyclinE在膀胱移行细胞癌中表达的意义
Author: Jiangsheng FANG ; Jianrong WANG ; Jianhua WANG ; Junsheng LIU ; Fenlin XU
Publication Type:Journal Article
Keywords: Urinary bladder neoplasms; p27kip1; CyclinE; CyclinD1; Bladder transitional cell carcinoma
From: Cancer Research and Clinic 2009;21(4):254-255,258
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of p27kip1, CyclinE, CyclinD1 in bladder transitional cell carcinoma (BTCC), and evaluate their relationship with turnout cell proliferation. Methods To study the expression of p27kip1, CyclinE and CyclinD1 protein in 41 cases of paraffin-embedded BTCC tissue and in 12 cases of cystitis tissues by immunohistochemical method SP. Results There was a negative relationship between p27kip1 expression and clinical stage and pathological grade.There was no relationship with lymph node metastasis (P>0.05). There was a positive relationship between CyclinE expression and clinical stage, pathological grade and lymph node metastasis (P<0.05). There was no relationship between CyclinD1 expression and clinical stage, pathological grade and lymph node metastasis (P>0.05). Conclusion The results of this study showed that the abnormal expression of p27kip1, CyclinE, may play important roles in the genesis and progression of BTCC. CyclinD1 may take activation in the early term of BTCC.