The effect of mild hypothermia on the content of Ca~(2+)、Mg~(2+)、EAA in rat brain tissue and ET in plasma after acute cerebral infarction
- VernacularTitle:亚低温对大鼠急性脑梗死后脑组织内Ca~(2+)、Mg~(2+)、EAA及血浆ET变化的影响
- Author:
Zhichao LIU
;
Chengyan LI
;
Hongjuan DONG
;
Shanping MAO
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Mild hypothermia;
Ca 2+;
Mg 2+;
EAA;
ET
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of m il d hypothermia on the content of Ca 2+、Mg 2+、EAA in rat brain tissue and ET in plasma after acute cerebral infarction. Methods Forty-eight Sprague-Dawley rats were randomly assigned into trial group and control group. Using the method of reformed line-thrombosis,the cerebral in farction models were established. The rats in the trial-group were cooled by mi ld hypothermia for half an hour, while those in the control group were subjected to no disposal. Every group was divided into 4 sub-groups according to the pos t-infarction disposal time. Every sub-group was composed of 6 SD rats and kill ed at the time points of 1 hour,2 hour,4 hour and 8 hour after infarction, respe ctively. Then the content of Ca 2+、Mg 2+、EAA in rat brain tissue an d ET in plasma were measured. ResultsThe post-infar ction content of Ca 2+、EAA and ET of trial-group increased mildly and Mg 2+ reduced very little. There was a significant statistical difference bet ween the trial group and the control group. Conclusion Mild hypothermia may significantly reverse the increase of the content of Ca 2+ and EAA and the fall of Mg 2+ and the increment of ET in plasma as well after acute cerebral infarction in experimental animals. So as a result, m ild hypothermia possesses protective effect on brain.
