Effect of glutathione on chronic liver injury in rat
- VernacularTitle:还原型谷胱甘肽对大鼠慢性肝损伤的保护作用
- Author:
Xiaofeng SHI
- Publication Type:Journal Article
- Keywords:
Glutathione;
Chronic liver injury;
Rat
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the prevention of glutathione(GSH)against chronic liver injury in rat.Methods:The chronic liver injury model was made by intracutaneous injection of carbon tetrachloride twice a week in rats for 24 times.From the 8th week after the carbon tetrachloride injection,GSH was given by oral or peritoneal administration once a day for 60 days.The animals were sacrificed at the end of the experiment.The serum level of ALT,AST were measured.The liver tissue was studied with histopathological or immunohistochemical assay.Results:GSH markly decreased the serum level of ALT,AST and improved liver tissue inflammation and lessend the liver fibrosis in histopathology compared with the model group.In the immunohistochemical stain,the deposition of type Ⅰ collagen of liver tissue significantly decreased in GSH treatment group compared with the model group.Conclusion:GSH can protect live from injury induced by toxic material.
