Influence of Gusongbao Capsule on Osteoporosis in Ovariectomized Rats
- VernacularTitle:骨松宝对雌性去势大鼠骨质疏松症的影响
- Author:
Guilin ZHANG
;
Guangyou REN
;
Siyuan LIU
;
Jun LI
- Publication Type:Journal Article
- Keywords:
@ Gusongbao capsule/pharmacology;
Osteoporosis/TCD therapy;
Disease models, animal
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of Gusongbao capsule for osteoporosis. Methods Experimental osteoporosis rat models were established by extirpation of bilateral ovaries of female rats. Bone morphological indexes, blood biochemical indexes, and daily output of calcium and phosphorus in urine in the Gusongbao treatment group and control group were determined. Results Compared with the control, the average width of bone trabecula, relative bone volume, average thickness of bone cortex, bone calcium, and the average gray degree of femoral head and femoral shaft were high, and the serum calcitonin (CT) and blood calcium increased markedly in the treatment group. High-dose and moderate-dose Gusongbao increased number of osteocytes in per unit area of bone trabecula, decreased serum alkaline phosphatase (ALP) level and reduced the daily output of urine calcium. Conclusion Gusongbao capsule can obviously inhibit the excessive bone transformation and promote the re-construction of bone and exerts an antagonistic effect on osteoporosis in ovariectomized rats.
