Role of the PI3K-AKT-mTOR signalling in cell differentiation
- VernacularTitle:PI3K-AKT-mTOR信号通路在细胞分化中的作用
- Author:
Yan MENG
;
Reifang MI
;
Chunhua ZHAO
- Publication Type:Journal Article
- Keywords:
PI3K;
PTEN;
TSC1/2;
mTOR;
differentiation
- From:
Basic & Clinical Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Phosphatidylinositol-3-kinase(PI3K),AKT,TSC1/2,and the mammalian target of rapamycin(mTOR) signaling cascade involves many cellular processes including apoptosis,growth,proliferation and differentiation,This pathway has been found to be the most variable one in human tumors.As tumor is a poorly differentiated disease,this review examines the role of the PI3K-AKT signal pathway in cell differentiation and tumor development.
