Counteractive Mechanism of Tongmai Injection for Excitotoxicity in Rats with Cerebral Ischemia/Reperfusion
- VernacularTitle:通脉注射液对脑缺血再灌注大鼠兴奋性毒性作用的干预机制
- Author:
Zhaohong ZHU
;
Zhu DING
;
Maocai LIU
- Publication Type:Journal Article
- Keywords:
TONGMAI INJECTION/pharmacology;
CEREBRAL ISCHEMIA/TCD therapy;
ASTRAGALUS MEMBRANACEUS/ther. use;
LEONURUS HETEROPHYLLUS/ther. use;
GLUTAMIC ACID/analysis;
RECEPTORS, N-METHYL-D-ASPARTATE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To explore the counteractive mechanism of Tongmai Injection (IT) for excitotoxicity in rats with cerebral ischemia/reperfusion by observing the glutamic acid (Glu) content and N-methyl-D-aspartate (NMDA) receptor activity in rats cortex. [ Methods ] Rat models with cerebral ischemia/reperfusion were established by four-vessel occlusion. Glu content and NMDA receptor activity were examined by radioimmunoassay and the effects of TI on Glu and NMDA receptor were also observed. [ Results ] Glu content and NMDA receptor activity were both increased in the model group and TI could counteract the above changes. [Conclusion] Cerebral ischemia/reperfusion can induce excitotoxicity and TI can protect the cerebral cortex.
