Effect of SINI TANG on contraction of aortic rings induced by high K~+ and phenylephrine
- VernacularTitle:四逆汤对高钾和去氧肾上腺素收缩主动脉环效应的影响
- Author:
Chunhong SHAO
;
Xiaoliang WANG
- Publication Type:Journal Article
- Keywords:
SINI TANG (SNT);
phenylephrine (Phe);
Propranolol (Pro);
Bay K8644 (BK) SINI TANG is a decoction with Chinese prescription of R adix Aconi ti Lateralis Preparata, Rhizoma Zingiberis and Radix Glycyrrhizae. It is used in the treatment of
- From:
Chinese Traditional and Herbal Drugs
1994;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To study the effects of SINI TANG (SNT) on the rat aortic rings pre-contracted by high K + and phenylephrine (Phe). Methods The effects of SNT on the aortic rings in the presence of 60 mmol/L KCl and Phe (1?10 -9 -1?10 -4 mmol/L) were observed and t heir me chanisms were studied after treatment with Propranolol (Pro, 3?10 -6 mmol/ L) and Bay K8644 (BK, 1?10 -5 mmol/L) as tool drugs. Results SNT inhibited the contraction induced by cumulative Phe and decreased the maximum tension (T max ); Pro couldn't influe nce the effects of SNT. SNT attenuated the amplitude of contractile effect of hi gh K +; BK couldn't reverse the effects of SNT. Conclusion SNT can shift the dose-response curve to the right and decrease the T max . It shows that SNT is a kind of noncompe titive antagonism. SNT decreases the effect of high K + against contraction of the artery. BK, a L-type Ca 2+ channels activator, couldn't recover the inhibition induced by SNT. The results suggest that SNT inhibit ? 1 recep tor, while calcium channel may not be involved in attenuating the effect of SNT on high K +-induced contraction.
