Study on the role of Th cells in dextran sulphate sodium induced murine colitis
- VernacularTitle:T辅助细胞在右旋葡聚糖硫酸钠诱导的小鼠结肠炎中的作用研究
- Author:
Renwei HU
;
Qin OUYANG
;
Feng LUO
- Publication Type:Journal Article
- Keywords:
Colitis;
T help cell;
Dextran sulfate sodium
- From:
Chinese Journal of Digestion
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of Th cells in dextran sulfate sodium (DSS) induced murine colitis. Methods The ratios of Th1/Th2 cells intestinal mucosa and splenic monocytes (SMC) of mouse with DSS induced murine colitis were detected by FCM with two color intracellular cytokine staining. Results (1) In lamina propria mucosa cell (LPMC) of murine colonic mucosa from the acute model, Th1 cell was (8.90?1.23)%, significantly higher than that in the control( P 0.05). The ratio of Th1/Th2 was 3.09?1.18, significantly higher than that in the controls( P
