Effect of different dosage of tamoxifen on the morphology of the mammary hyperplasia of rats
- VernacularTitle:三苯氧胺对大鼠乳腺增生形态学的影响
- Author:
Changqing GAN
- Publication Type:Journal Article
- Keywords:
Tamoxifon;
Estradiol;
Progesterone;
Mammary hyperplasia
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of different dosage of tamoxifen (TAM) on the morphological change of experimental mammary hyperplasia.Methods:The animal model of mammary hyperplasia of Wistar rats was induced with estradiol and progesterone. One hundred and eighty female Wistar rats were selected randomly into group A (control group ) , group B (model control group), group C (166.7 ?g dosage of TAM),group D(333?g dosage of TAM) ,group E(500?g dosage of TAM),and group F(667?g dosage of TAM) and fed for 2 months.Samples of breasts were collected and observed under light microscope and electronmicroscope.Results:For light microscope observation :there were obvious difference between premedication and postmedication in group E and F, respectively ( P 0. 05), implying that 500 ?g dosage and 667 ?g dosage of TAM had obvious inhibitory effect on mammary hyperplasia under light microscope.Conclusion:Through light microscope and electronmicroscope observation,TAM especially 500?g and 667?g dosage proves to have obvious inhibitory effect on mammary hyperplasia induced by estradiol and progesterone.
