NF-? B inhibitor-PDTC enhance TNF-? induced cytotoxicity in breast cancer cells
- VernacularTitle:NF-?B抑制剂PDTC增敏TNF-?对乳腺癌细胞的毒性作用
- Author:
Gang TU
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Tumor necrosis factor-?;
Nuclear factor kappa B
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of NF-? B inhibitor-PDTC on TNF-? induced cytotoxicity in breast cancer cells.Methods:The cell survivals of breast cancer cell lines MCF-7 and MDA-MB-435s were measured by MTT assay in vitro.MDA-MB-435s cells were implanted into BALB/C mice. Animal tumor models were treated with TNF-?, PDTC and TNF-? plus PDTC.Results:The growth of two breast cancer cell lines was not inhibited by either TNF-?(2000U/mi or less)or PDTC.However,both breast cancer cells treated with TNF-?(2000U/mi)plus PDTC(50? mol)showed significant growth inhibition as compared with controls. In vivo, the growth of implanted tumor was significantly reduced in volume in mice treated with TNF-?(7.5?10 6U/kg,ip,bid) plus PDTC(50mg/kg,ip,bid) as compared with controls( P
