Relationship of STAT3 and VEGF in non-small cell lung cancer
- VernacularTitle:STAT3与VEGF在非小细胞肺癌中的表达及关系
- Author:
Wenchun XU
- Publication Type:Journal Article
- Keywords:
Non-small cell lung cancers;
Signal transducers and activators of transcription 3;
Vascular endothelial growth factor;
Immunohistochemistry
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression of STAT3 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) and their relationship.Methods:SABC immunohistochemistry was used to detect the expression of STAT3 and VEGF in non-small tissues of 40 cases.Results:(1)The expression of STAT3 in NSCLCs had a obvious relation with the tumor cell differentiation and lymph node metastasis.No obvious difference in STAT3 expression was found among different tumor sizes of tumor types.(2)The expression of VEGF in NSCLCs had a significant relation with tumor size and lymph node metastasis.There was no significant difference between VEGF expression and tumor types and tumor cell differentiation.(3)There was significant positive correlation between the expression of VEGF and STAT3 in NSCLCs.Conclusion:STAT3 and VEGF may play an important role in the development of NSCLC.We identify that VEGF gene is regulated directly by STAT3 protein.
