Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder
- VernacularTitle:膀胱癌组织中MMP9、MMP2与PCNA及临床指标的研究
- Author:
Dongtao PENG
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Matrix metalloproteinase;
Immunohistochemistry
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression and clinical significance of matrix metalloproteinase(MMP9,MMP2)in transitional cell carcinoma of bladder(TCCB).Methods:Applying S-P immunohistochemical technique,expression of MMP9 and MMP2 was studied in 64 TCCB.Results:There was 60.93%(39/64) with MMP9 and 42.19%(27/64) with MMP2 expression.There was a significant correlation between MMP9 expression and PCNA,pathological grade,clinical stage,tumor size.However,the relationship had not been found with patient age,sex as well as the number of tumor.Conclusion:MMP9 appears to be an independent biological marker for predicting prognosis and comprehensive treatment of TCCB.
