The change of serum and urinary NO and the relation between NO and blood pressure in patients with chronic glomerulonephritis at pre-uremic phase
- VernacularTitle:慢性肾小球肾炎非尿毒症期患者血、尿NO与血压的关系
- Author:
Xuemei CHEN
- Publication Type:Journal Article
- Keywords:
Chronic glomerulonephritis;
Nitric oxide;
Blood pressure
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the change of serum and urinary nitric oxide (NO) and the relation between NO and blood pressure in chronic glomerulonephritis (CGN) patients at pre-uremic phase.Methods:The levels of serum and urinary NO - 3/NO - 2 were measured in 92 cases of CGN at pre-uremic phase and 31 normal subjects by chemical colorimetry.Results:The levels of serum and urinary NO - 3/NO - 2 in CGN patients at pre-uremic phase were significantly lower than those in the control group.The levels of serum and urinary NO - 3/NO - 2 of the hypertension group were significantly lower than those of the normal blood pressure group and the control group;furthermore,the levels of urinary NO - 3/NO - 2 of the normal blood pressure group were significantly lower than those of the control group.There was significantly inverse correlation between the levels of serum NO - 3/NO - 2 and mean arterial pressure (MAP),and also there was significantly inverse correlation between the levels of urinary NO - 3/NO - 2 and MAP.Conclusion:In CGN patients at pre-uremic phase,hypertension may be related to the insufficiency of NO.
