Effect of Shengmai Chenggu Prescription in Preventing Endothelial Cells from Endotoxin -Induced Damage
- VernacularTitle:生脉成骨方对内毒素致血管内皮细胞损伤的保护作用研究
- Author:
Chuanyi XU
;
Yueguang FAN
;
Wei HE
;
Haibin WANG
;
Hao YUAN
- Publication Type:Journal Article
- Keywords:
Shengmai Chenggu Prescription/pharmacology;
Cell culture;
Endotoxins/adverse effects;
Vascular endothelial cells/drug effects
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Shengmai Chenggu Prescription (SCP) on the damage of endothelial cells (EC) induced by endotoxin. Methods EC obtained from rabbit's aorta were cultured and were treated with endotoxin and serum containing SCP respectively. Histological changes and function of the cultured cells were observed under light microscope and electron microscope and with MTT method . Results Endotoxin could result in the pathologic injury of cultured EC and inhibit the proliferation of the cells. Serum containing SCP could increase the activity of EC and promote its proliferation. Conclusion SCP can protect endothelial cells from damage induced by endotoxin.
