Influence of Zhenxintong Oral Liquid on Thrombus-Associated Marker Levels in Coronary Heart Disease
- VernacularTitle:镇心痛口服液对冠心病血栓相关分子标志物水平的影响
- Author:
Zhiyu YUAN
;
Haibo YUAN
- Publication Type:Journal Article
- Keywords:
Zhenxintong Oral Liquid/pharmacology;
@Thrombus Associated Marker /drug effects;
Coronary Heart Disease;
Disease models,animal
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide evidence for the pharmacological action of blood-activating and blood-stasis-dissipating medicines by studying the influence of Zhenxintong Oral Liquid (ZOL) on thrombus-associated marker levels in coronary heart disease with blood-stasis syndrome. Methods Forty male Wistar rats were randomly allocated to 5 groups: normal group,model group,large-dose ZOL group,small-dose ZOL group and Compound Danshen Drip Pill(CDDP) control group. Blood-stasis models were established by peritoneal injection of dexamethasone (0.25mg?kg-1?d-1). After 8 days of treatment,levels of activated partial thromboplastin time (APTT),antithrombin -Ⅲ(AT-Ⅲ),tissue-type plasminogen activator (t-PA) and tissue-type plasminogen activator inhibitor (PAI) in blood from abdominal aorta were determined. Results AT-Ⅲlevel in the two ZOL groups and in CDDP control group was significantly higher than that in model group(P 0.05). t-PA level was higher and PAI level was lower in large-dose ZOL group than that in CDDP control group (P
