Preventive Effect of Tangshenkang Mixture on Experimental Diabetic Nephropathy
- VernacularTitle:糖肾康合剂对实验性大鼠糖尿病肾病的预防作用
- Author:
Ning SU
;
Zhicheng LIAN
- Publication Type:Journal Article
- Keywords:
Tangshenkang Mixture/pharmacology;
Diabetic nephropathy/TCD therapy;
Diabetic nephropathy/pathology;
Disease models,animal
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Tangshenkang Mixture (TM) on preventing diabetic nephropathy (DN). Methods SD rat model of diabetes was established by intraperitoneal injection of streptozotocin (STZ). Contents of blood sugar,urine sugar and urine albumin in rats were measured. The pathological changes of unilateral kidney were also observed under microscope by HE and PAS staining. Glomerulus dimensions,capillary vessel dimensions and PAS-positive matter area were measured with Pathological Picture Analyzing System. Results ①Obvious albuminuria,enlargement of glomerulus and capillary vessel,increase of PAS-positive matter area were found in model group. ②Urinary protein content in TM group was significantly lower than that in model group and western medicine group(P
