Effect of Ganoderma Lucidum on Counteracting Lipid Peroxidation in Cultured Vascular Smooth Muscle Cells of Rats
- VernacularTitle:灵芝对体外培养的大鼠主动脉平滑肌细胞的抗脂质过氧化作用
- Author:
Xianhua DU
;
Weimin WANG
;
Xinrong GONG
;
Longshun YU
- Publication Type:Journal Article
- Keywords:
Ganoderma Lucidum /pharmacology;
Cell culture;
Vascular smooth muscle cell/drug effects;
Lipid peroxide;
Superoxide dismutase
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Ganoderma Lucidum (GL) on counteracting lipid peroxidation in cultured vascular smooth muscle cell(VSMC)and to explore its therapeutic mechanism for atherosclerosis. Methods The effects of GL on the content of lipid peroxide(LPO)and the activity of superoxide dismutase(SOD)in medium were studied . Results GL decreased LPO content and increased SOD activity in a dose-effect manner. Conclusion GL can counteract the lipid peroxidation in VSMC and its therapeutic mechanism for atherosclerosis may be related to the counteraction of lipid peroxidation and enhancement of endogenous antioxidase activity.
