RP-HPLC determination of paracetamol, caffeine and chlorphenamine maleate in Compound Ganmaoling Tablets
- VernacularTitle:RP-HPLC测定复方感冒灵片中对乙酰氨基酚、咖啡因和马来酸氯苯那敏的含量
- Author:
Bo WANG
;
Jian WANG
;
Peng DONG
- Publication Type:Journal Article
- Keywords:
RP-HPLC;
paracetamol;
caffeine;
chlorphenamine
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish a method for the determination of paracetamol, caffeine and chlorphenamine maleate in Compound Ganmaoling Tablets. Methods: The RP-HPLC was conducted on a Phenomenex C 18 column(5?m,250mm?4.0mm) with methanol: water: acetic acid(35∶65∶1.5) as a mobile phase, detect wavelength at 270nm. Results: Paracetamol, caffeine and chlorphenamine maleate respectively showed good linear relationship in the following concentrations of ranges:50.4～117.6?g?mL -1,3.6～8.4?g?mL -1,0.84～1.96?g?mL -1; The average recoveries were obtained as 99.9%,99.8%,100.0%(n=6); respectively. Conclusion: The method was simple, sensitive, accurate and suitable for the determination of three constituents in Compound Gamaoling Tablets.
