Gene expression of MMP-9 in MCAO rats and the influence of of Buyanghuanwu Decoction on it
- VernacularTitle:大脑中动脉阻塞大鼠MMP-9基因表达及补阳还五汤对其影响
- Author:
Ying GAO
;
Dingfang CAI
- Publication Type:Journal Article
- Keywords:
blood-brain barrier;
permeability;
MMP-9;
cerebral ischemia;
reperfusion;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The experiment was undertaken to explore the blood-brain barrier permeability and the gene expression of matrix metalloproteinase-9 (MMP-9) in ischemic cerebra and the impact of Buyanghuanwu Decoction on them. Methods: The (middle cerebral artery occlusion, MCAO) rat model was used. At 1h, 3h, 24h, 48h, 5d after reperfusion. They were measured. Results: In treatment group, the BBB permeability and the MMP-9 gene expression decreased. Conclusion: Buyanghuanwu Decoction can protect the BBB by inhibiting the MMP-9 gene expression.
