Research on the expression of P-selectin in renal tissue of patients with Henoch-Schnlein purpura nephritis
- VernacularTitle:紫癜性肾炎患者血和肾组织P选择素的表达及意义
- Author:
Yanxia WANG
;
Aiping ZHANG
;
Yingwei ZHANG
;
Lei ZHANG
- Publication Type:Journal Article
- Keywords:
Nephritis;
Purpura;
P-selectin
- From:
Chinese Journal of Rheumatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of adhesion molecules P-selectin (CD62P) as a pathogenic factor in Henoch-Schonlein purpura nephritis (HSPN) patients.Methods The expression of adhesion molecules CD62P marked by fluorescent monoclonal antibody in renal biopsy tissue and peripheral blood was studied by flow cytometry in patients with HSPN.The renal tissue was collected and analyzed by light microscopy (HE,PAS,Masson,PASM).Results ① CD62P expressed in renal tissue of 27 cases among all 32 patients with HSPN (84.4%).It expressed mainly in glomerular mesangial area and capillary vessels,then,interstitial small blood vessels,renal tubule.CD62P most significantly expressed in type Ⅲ and Ⅳ,then the type Ⅱ and the last type Ⅰ.② Thirty-two patients of HSPN were highly expressed on CD62P in peripheral blood than those of control group (P
