Comparison of Protective Mechanism of Zuojin Pill and Fan Zuojin Pill on Gastric Mucosa

VernacularTitle:左金丸和反左金对大鼠胃粘膜保护机制的比较研究
Author: Yanfen CHEN ; Weiwen CHEN ; Ruliu LI ; Fuqiang YE ; Songfen XU ; Huaigeng PAN
Publication Type:Journal Article
Keywords: ZUOJIN PILL/pharmacology; FAN ZUOJIN PILL/pharmacology; GASTRIC MUCOSA/drug effects
From: Journal of Guangzhou University of Traditional Chinese Medicine 1999;0(02):-
CountryChina
Language:Chinese
Abstract: [ Objective] To compare the protective mechanism of Zuojin Pill (Rhizoma Coptidis: Fructus Evodiae = 6:1) and Fan Zuojin Pill (Rhizoma Coptidis: Fructus Evodiae = 1: 6) on gastric secretion and gastric mucosal barrier. [Methods] Pylorus - ligated rat model was applied. Rats were divided into normal saline group, Zuojin Pill groups (1.4 g/kg and 2.8 g/kg) and Fan Zuojin Pill groups (1.4g/kg and 2.8g/kg) and then the drugs were given by duodenal feeding. Gastric secretion and gastric mucus synthesis were examined. [Results] Zuojin Pill and Fan Zuojin Pill (1.4 g/kg and 2.8 g/kg) both inhibited gastric secretion and decreased total acid output and pepsin activity in a dose- effect manner. Zuojin Pill and Fan Zuojin Pill also increased the content of gastric adherent mucus (GAM) and tended to elevate the mucus level in gastric juice. [Conclusion] The preventive mechanism of Zuojin Pill and Fan Zuojin Pill on gastric mucosa may be related to the regulation of gastric secretion and gastric mucus synthesis.