Effect of Blood-activating and Stasis-removing Herbs on Proliferation and Apoptosis of Gastric Mucosa Cells in Experimental Chronic Atrophic Gastritis Rats
- VernacularTitle:活血化瘀中药对慢性萎缩性胃炎大鼠细胞增殖及凋亡的影响
- Author:
Qun DU
;
Rujun WANG
;
Qin XU
;
Yanli WU
- Publication Type:Journal Article
- Keywords:
GASTRITIS, ATROPHIC/TCD therapy;
BLOOD ACT STASIS REMOV DRUGS/ther. use;
GASTRIC MUCOSA/ drug effects;
CELL DIVISION;
APOPTOSIS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the effects of blood-activating and stasis-removing (BASR) herbs on the proliferation and apoptosis of gastric mucosa cells (GMC) in experimental chronic atrophic gastritis (CAG) rats. [Methods] CAG rat models were established with comprehensive method and then were given BASR herbs. Argyrophilic protein of nucleolar organizer regions ( AgNOR) count was carried out after silver nitrate staining. The expression of proliferating cell nuclear antigen (PCNA) was examined with immunohistochemical method and apoptosis was detected by in-situ cell-end labeling method. [Results] The number of AgNOR and the indexes of PCNA and apoptosis were increased in CAG model rats ( P
