Experimental Study of Changyanqing for Colitis Induced by Dextran Sulfate Sodium
- VernacularTitle:肠炎清治疗葡聚糖硫酸钠结肠炎的实验研究
- Author:
Yonghui LU
;
Wenhong CHEN
;
Pinjin HU
;
Sheng HU
- Publication Type:Journal Article
- Keywords:
CHANGYANQING/ther. use;
COLITIS, ULCERATIVE/TCD therapy;
PEROXIDASE/drug effects;
SEVERITY OF ILLNESS INDEX;
REGULATING QI;
ACTIVATING BLOOD;
STRENGTHENING SPLEEN
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the effects of Changyanqing, a Chinese prescription with the actions of regulating qi and activating blood, strengthening spleen-qi and clearing away heat, on ulcerative colitis (UC) and to explore its therapeutic mechanism . [ Methods ] Forty mice were randomized into Changyanqing group ( Group A ), salicylazosulfapyridine group (Group B), Changyanqing and salicylazosulfapyridine (Group C) and model group (Group D). Mouse models with UC were induced by dextran sulfate sodium (DSS). Effects of Changyanqing on disease activity index (DAI) and intestinal myeloperoxidase (MPO) content were observed. [Results] Changyanqing reduced DAI and MPO activity and its effect was similar to that of salicylazosulfapyridine. [ Conclusion ] Changyanqing exerts a better effect in treating DSS-induced UC and one of its therapeutic mechanisms may be related to the reduction of MPO activity.
