Effects of Dachengqi Decoction on Systemic Inflammatory Response Syndrome in Mice
- VernacularTitle:大承气汤对全身性炎症反应干预作用的实验研究
- Author:
Xing WAN
;
Qianxian LIU
;
Peixun WANG
- Publication Type:Journal Article
- Keywords:
DACHENGQI DECOCTION/pharmacology;
SEPSIS SYNDROME;
TUMOR NECROSIS FACTOR-ALPHA/blood;
INTERLEUKIN 6/blood;
ENDOTOXINS/blood;
DISEASE MODELS, ANIMAL
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the mechanism of Dachengqi Decoction (DCD) in treating systemic inflammatory response syndrome ( SIRS). [ Methods ] Mouse models induced by zymosan A were administered with DCD orally. Serum endotoxin level was detected by limulus assay and TNF-? and IL-6 levels by radioimmunoassay 6, 12 and 24 hours after medication. [Results] Serum levels of endotoxin, TNF-? and IL-6 were increased in SIRS mice. After treatment with DCD, serum endotoxin level was decreased at the 6th and 12th hour ( P
