An Experimental Study of Niaoduling Granule for Chronic Renal Failure
- VernacularTitle:尿毒灵治疗慢性肾功能衰竭的药效学研究
- Author:
Xiaofeng YAO
;
Shuifu TANG
- Publication Type:Journal Article
- Keywords:
NIAODULING GRANULE/pharmacology;
RENAL FAILURE, CHRONIC/TCD therapy;
TRANSFORMING GROWTH FACTOR ?1;
GLOMERULUS SCLEROSIS;
DISEASE MODELS, ANIMAL
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To observe the effects of Niaoduling Granule (NG) on renal function in rats with chronic renal failure (CRF) and its relationship with renal transforming growth factor (TGF) ?1. [Methods] CRF rat models were established by 5/6 subtotal nephrectomy and then the model rats were randomized into model group (Group B), NG group (Group C) and placebo control group (Group D) and other 8 rats served as mimic operation group (Group A) . Biochemical indexes, metabolic parameters and pathological features in kidney were examined and expression of renal transforming growth factor (TGF) ?1 was determined by immunohistochemical assay. [Results] Renal hypofunction, disorder of electrolyte, decrease of hemoglobin and CRF features were found in Group B. After treatment, renal function was improved and glomerulus-sclerosis index (GSI) and expression of renal TGF ?1 were decreased in Groups C and D (P
