Pattern of protein kinase C isoforms expression in retinal vasculature of diabetic rats
- VernacularTitle:糖尿病大鼠视网膜血管蛋白激酶C同工酶表达模式
- Author:
Bo ZHOU
- Publication Type:Journal Article
- Keywords:
Protein Kinase C;
Isoenzyme;
Vessel;
Diabetes mellitus
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
180% elevation of PKC activity in the retinal vasculature.????????except ??? distributed in the membrane and cytosolic fraction in retinal vessels in normal or diabetic rats,the expression of ?????-PKC significantly increase in the membrane pool OD Value 282%?32%?340%?26%?187%?14% respectively ,but ?????-PKC expression significantly decrease in cytosolic pool in retinal vessels of diabetic rats compared with nondiabetic rats,OD value 71%?11%?63%?8%?84%?6%,respectively,however ? isoenzym expression in cytosolic pool significantly increase 208%?6%,compared with normal rats.Conclusion:Diabetes can induce the translocation of ?????-PKC from cytosol to membrane pool,but ? isoform translocated from membrane to cytosol pool in retinal vessels of diabetic rats.
