The Influence of a Muscle Relaxant on Bispectral Index during the Propofol Induction of Anesthesia.
10.4097/kjae.2008.54.4.373
- Author:
Yun Chul SHIN
1
;
Soon Im KIM
;
Si Young OK
;
Sun Chong KIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Soonchunhyang University College of Medicine, Seoul, Korea. soonnim@hosp.sch.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
bispectral index;
electromyogram activity;
muscle relaxant;
propofol
- MeSH:
Anesthesia;
Anesthesia, General;
Double-Blind Method;
Humans;
Muscles;
Neuromuscular Blockade;
Propofol;
Prospective Studies;
Unconsciousness;
Vecuronium Bromide
- From:Korean Journal of Anesthesiology
2008;54(4):373-377
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Although neuromuscular blockade can influence the bispectral index (BIS) during anesthesia, there have been contradictory reports regarding its effects. The purpose of this study was to investigate whether a muscle relaxant affected the level of BIS during propofol anesthesia. METHODS: Forty-eight healthy patients undergoing elective surgery under general anesthesia were enrolled in this prospective, randomized, double-blind study. All patients received an effect-site targeted concentration of propofol via a TCI system that was titrated until loss of consciousness occurred. The patients then received either an injection of vecuronium (relaxant group, n = 24) or normal saline as a placebo (placebo group, n = 24) at 3 minutes after loss of consciousness. The BIS and electromyogram (EMG) activity were recorded from anesthetic induction to 4 minutes after injection of the vecuronium or placebo. RESULTS: The BIS significantly decreased after injection in both groups (P < 0.05), however, the decrease in the BIS was larger in the relaxant group than in the placebo group (P < 0.05). The decrease of EMG activity was not significantly different between the two groups after administration of vecuronium or placebo. CONCLUSIONS: During propofol induction of anesthesia, a muscle relaxant decreased BIS significantly without decreasing the EMG activity.
