Expressions and significance of P-gp and nm23,P53 in multiple primary breast carcinoma tissues
- VernacularTitle:P-gp和nm23、P53在多原发乳腺癌组织的表达及意义
- Author:
Zhijun SUN
- Publication Type:Journal Article
- Keywords:
Multiple primary breast carcinoma;
P-gp;
nm23;
P53
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expression of P-gp and nm23,P53 in multiple primary breast carcinoma tissues and to evaluate the prediction significance in occurrence of the second primary carcinoma. Methods:Expression of P-gp,nm23,P53 in 34 benign and malignant breast paraffin-embedded specimens, the difference of the rate and the intensity of positive reaction of P-gp,nm23,P53 were checked.Results:The positive rate of P53 was significantly increased in malignant breast tissues compared with benign breast tissues,the positive intensity of P53 was significantly increased in multiple breast carcinoma tissues compared with the tissues of no occurrence of breast carcinoma. Conclusion:The expression of P53 may indicate the proliferating activity of carcinoma cell. The positive intensity of expression of P53 can be certain valuable in prediction of the occurrence of second primary carcinoma.
