Effect of Langchuangjing Granule on Expression of CD4~+CD8~+ and CD54 in Peripheral Blood of Lupus Mice
- VernacularTitle:狼疮静颗粒对狼疮样小鼠外周血CD4~+、CD8~+及CD54表达的影响
- Author:
Fangshi ZHU
;
Shi JIN
;
Yue WANG
;
Wei DING
;
Jue ZHOU
;
Lanwe XU
- Publication Type:Journal Article
- Keywords:
Langchuangjing Granule /pharmacology;
Lupus erythematosus,systemic /dru g therapy(TCD);
Lupus erythematosus,systemic /patholog y;
T -Lymphocytes;
Intercellular adhesion molecule -1
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immunoregulatory mechanism of Langchuangjing Granule(LG)in different dosages in lupus mice.Methods Three -month female NZB /NZWF1mice were treated with LG in three differen t dosages for six weeks and then the effect of LG on t he expression of CD4 + ,CD8 + and CD54in peripheral blood was obse rved.Re-sults LG in different dosages showed a tend ency of increasing the content of CD4 + and CD8 + ,decreased the serum con-tent of CD54and inhibited the hyper -expressions of CD54on the surface of lymphocyte and monocyte in plasma.T he above effects were stronger in middl e -and high -dosage of LG.Conclusion LG can improve the immune function an d restrain the excessive immunoreaction of lupus mice.
